What do you use to clean up audio on talking head videos?

+1 on the mic. after that deal with the room: rugs, curtains, a sofa behind the camera. noise removal handles hum fine, echo is much harder to fix afterwards.

Adobe Podcast's Enhance Speech for quick stuff, the voice isolation in DaVinci Resolve if I'm editing there anyway. Pull the strength back or it sounds robotic. honestly the bigger win was moving the mic closer.